cómo se transporta la glucosa través de la membrana celular? diana díaz hernández, luis carlos burgos herrera de la célula para su ingreso requiere una. RESUMEN El transporte de la glucosa a través de la membrana plasmática de a sodio (SGLT) y los sistemas facilitadores del transporte de glucosa (GLUT). Se han descrito dos sistemas de transporte de glucosa y de otros monosacáridos : y los transportadores de glucosa llamados GLUT (glucosa transporters).

Author: Vudokazahn Zuzil
Country: Bermuda
Language: English (Spanish)
Genre: Love
Published (Last): 11 January 2018
Pages: 203
PDF File Size: 8.58 Mb
ePub File Size: 4.8 Mb
ISBN: 292-8-68129-810-2
Downloads: 66670
Price: Free* [*Free Regsitration Required]
Uploader: Vudoshicage

Efeito do diabetes sobre os transportadores de glicose de epitelio renal. Glucose transporters are a wide group of membrane proteins that facilitate the transport of glucose across the plasma membrane.

Transportador de glucosa

A topologia dos transportadores de glicose GLUTs inicialmente proposta por Mueckler e cols 2 para o GLUT 1, e posteriormente confirmada para as outras isoformas 12e pode ser vista na Figura 1.

Machado UF, Saito M. Decreased glucose transporter GLUT 4 content in insulin-sensitive tissues of obese aurothioglucose- and monosodium glutamate-treated mice. GLUT is a type of uniporter transporter protein.

Trahsportadores J Med Biol Res ; Am J Nephrol ;4: Expressed mostly in neurons where it is believed to be the main glucose transporter isoformand in the placenta. De Vivo’s syndrome, described in convulsive infants with hypoglycorrachia during normoglycaemia, has been attributed to a reduction in the GLUT1 content in endothelial cells at the blood-brain barrier. glut

N Engl J Med ; Physiol Rev ; J Clin Invest ; Molecular physiology of glucose transporters. From Wikipedia, the free encyclopedia. A Cellular And Molecular Approaoch. Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.


Levels in cell membranes are increased by reduced glucose levels and decreased by increased glucose levels. Nucleotide sequence of putP, the proline carrier of Escherichia coli K Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues. Vesicular glutamate transporter 1 SLC32A1. Molecular biology rransportadores mammaliam glucose transporters. Physiol Behav ; Ubiratan Fabres Machado Av.

Diabetes Care ; Most members vluts classes II and III have been identified recently in homology searches of EST databases and the sequence information provided by the various genome projects. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease.

Jackowski S, Alix JH. J Bacteriol ; Glucose, the main source of energy in the cell, is transported in most cells through facilitated diffusion, by the transporter proteins present in the plasma membrane.

By group SLC1—10 1: Diabetes Care trwnsportadores Regulation of glucose-transporter function. Membrane Transport and Metabolism.

Transportadores de glicose

In obesity, the GLUT4 content is not diminished providing that insulin sensitiveness is preserved. Is a high-affinity isoform, allowing it to transport even in times of low glucose concentrations.

However, it is responsible for the low level of basal glucose uptake required to sustain respiration in all cells.

Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity.

In Saccharomyces cerevisiae glucose transport takes place through facilitated diffusion. Cloning and functional expresssion in bacteria of a novel glucose transporter present in liver, intestine, kidney, and B-pancreatic islet cells.


The effect of adipose cell size on the measurement of GLUT 4 in white adipose tissue of obese mice.

In the adult, it is expressed at highest levels in erythrocytes and also in the endothelial cells of barrier tissues such as the blood—brain barrier. Whether mechanisms exist to promote cell-surface translocation of these transporters is not yet known, but it has clearly been established that insulin does not promote GLUT6 and GLUT8 cell-surface transportaores.

How transportdaores cite this article. Because glucose is a vital source of energy for all life, these transporters are present in all phyla. Retrieved from ” https: Tese – Mestrado -Escola Paulista de Medicina. Horm Metab Res ; Binding of glucose to one site provokes a conformational change associated with transport, and releases glucose to the other side of the membrane. Annu Rev Biochem ; Most non- autotrophic cells are unable to produce free glucose because they lack expression of glucosephosphatase and, thus, are involved only in glucose uptake and catabolism.

Transport proteins Integral membrane proteins. Is the insulin -regulated glucose transporter. Annu Gkuts Physiol ; Biochem J ;