Request PDF on ResearchGate | Encefalitis herpética neonatal: Caso Article in Revista chilena de pediatría 73(2) · March with. de los infectados con HCV-2 experimentaron recidivas a cinco años. VHS-1 puede causar infecciones orolabiales, enfermedad ocular, encefalitis herpética. Si esto ocurriera o si tuviera alguna inquietud, llame a su pediatra. cerebral causada por el virus, incluyendo meningitis o encefalitis.

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Inborn errors of metabolism in infancy: Recent advances in herpetjca diagnosis and treatment of inborn errors of metabolism have improved substantially the prognosis for many of these conditions. This makes it essential that the practicing pediatrician be familiar with the clinical presentation of these disorders. A practical clinical approach to the recognition of inborn errors of metabolism in the young infant is presented in this review.

Indications for specific laboratory studies are discussed. Guidelines are provided for the stabilization and emergency treatment of critically ill infants. This approach will identify those infants who will benefit from additional evaluation and specific treatment. Many of the inborn errors of metabolism, including urea cycle defects, organic acidemias, and certain disorders of amino acid herppetica, present in the young infant with symptoms of an acute or chronic metabolic encephalopathy.

Typical symptoms include lethargy, poor feeding, apnea or tachypnea, and recurrent vomiting. Therefore, appropriate laboratory testing for metabolic disorders should be performed in any infant who exhibits these findings. Although sepsis may be the initial consideration in a neonate with these symptoms, inborn errors of metabolism should always be in the differential diagnosis, particularly in a full-term infant with no specific risk factors.

Hypoglycemia may be the predominant finding in a number of inborn errors of metabolism, including glycogen storage disorders, defects in coneogenesis, and fatty acid oxidation defects.

The latter disorders, among the most common encountered, exhibit marked clinical variability and also may present as a sudden death, a Reye’s-like episode, or a cardiomyopathy. Jaundice or other evidence of hepatic dysfunction is the mode of presentation of another important group of inborn errors of metabolism including galactosemia, hegpetica tyrosinemia, neonatal hemochromatosis, and a number of other conditions.

A subset of lysosomal storage disorders may present very early with coarse facial features, organomegaly, or even hydrops fetalis. Specific patterns of dysmorphic features and congenital anomalies characterize yet another group of inherited metabolic disorders, such as Zellweger syndrome and the Smith-Lemli-Opitz syndrome. Each of these symptom complexes, and the appropriate evaluation of herpdtica affected infants, is discussed in more detail in this review Au.

Length and body mass index at birth and target height influences on patterns of postnatal growth in children born small for gestational age. Previous growth studies on children born small for gestational age SGA indicate that birth length, weight, and target height are important predictors for postnatal catch-up growth in SGA.

Their influences on different phases of catch-up growth are still not described. The aim of this study was to clarify the influences of target height, length, and nutritional status at birth on different phases of postnatal catch-up growth infancy, childhood, puberty in SGA and the long-term consequences.

Primary outcome measurements include heights, the changes in height standard deviation scores SDS during various phases of growth and relative risk for adult shortness. The difference in final height in children born SGA was attributable to their difference in target height and the magnitude of catch-up growth during the first 6 months of life, rather than the difference in length or body mass index BMI at birth.

Length at birth showed negative influence on catch-up growth during infancy 0 to 2 years of agebut no significant influence thereafter. Target height showed positive influence on catch-up growth from the onset of childhood.

Neither target height nor length and BMI at birth showed any significant influence on catch-up growth during puberty. The magnitude of catch-up growth during infancy, especially the first 6 months of life, is most critical in decreasing risk at adult shortness.

BMI at birth is not related to postnatal catch-up growth in infants born SGA, but birth length and target height are important. The genetic influence on catch-up growth appears to start from the onset of childhood. Being born short or becoming short during the first 2 years of life is similar in terms of risk for adult short stature Au.


Three-year multicenter surveillance of pneumococcal meningitis in children: To evaluate the antibiotic susceptibility of Streptococcus pneumoniae isolates obtained from the blood and cerebrospinal fluid of children with meningitis.

To describe and compare the clinical and microbiological characteristics, treatment, and outcome of children with meningitis caused by S pneumoniae based on antimicrobial susceptibility of isolates and the administration of dexamethasone.

Children with pneumococcal meningitis were identified from among a group of patients with systemic infections caused by S pneumoniae who were enrolled prospectively in the United States Pediatric Multicenter Pneumococcal Surveillance Study at eight children’s hospitals in the United States. From September 1, to August 31,children with episodes of pneumococcal meningitis were identified and data were collected by retrospective chart review.

Clinical and laboratory characteristics were assessed. All pneumococcal isolates were serotyped and antibiotic susceptibilities for penicillin and ceftriaxone were determined. Clinical presentation, hospital course, and outcome parameters at discharge were compared between children infected with penicillin-susceptible isolates and those with nonsusceptible isolates and for children who did and did not receive dexamethasone.

Clinical presentation, cerebrospinal fluid indices on admission, and hospital course, morbidity, and mortality rates were similar for patients infected with penicillin- or ceftriaxone-susceptible versus nonsusceptible organisms. However, the relatively small numbers of nonsusceptible isolates and the inclusion of vancomycin in the treatment regimen for the majority of the patients limit the power of this study to detect significant differences in outcome between patients infected with susceptible and nonsusceptible isolates.

Nonetheless, our results show that the nonsusceptible organisms do not seem to be intrinsically more virulent. However, children in the dexamethasone group more frequently required intubation and mechanical ventilation and had lower initial concentration of glucose in the cerebrospinal fluid than children who did not receive any dexamethasone. When we controlled for the confounding factor, severity of illness intubationthe incidence of any deafness and of any neurologic sequelae, including deafness, were no longer significantly different between children who did or did not receive dexamethasone.

Children with pneumococcal meningitis caused by penicillin- or ceftriaxone-nonsusceptible organisms and those infected by susceptible strains had similar clinical presentation and outcome. The use of dexamethasone was not associated with a beneficial effect in this retrospective and nonrandomized study.

Potential mechanisms for failure to eradicate group A streptococci from the pharynx.

To investigate the relative efficacy of orally administered cefadroxil and penicillin V in the treatment of group A streptococcal GABHS pharyngitis and the mechanism s responsible for failure of antimicrobial therapy to eradicate GABHS from the pharynx.

Neither beta-lactamase nor bacteriocin produced by normal pharyngeal flora are related to bacteriologic treatment failures in GABHS pharyngitis. Cefadroxil seems to be more effective than penicillin V in eradicating GABHS from patients classified as more likely to be streptococcal carriers.

However, among patients we classified as more likely to have bona fide GABHS pharyngitis, the effectiveness of cefadroxil and penicillin V seems to be comparable Au. Phenotyping of drug metabolism in infants and children: A look at the future of pediatric therapeutics: Lack of pediatric drug formulations.

Many drugs frequently used in infants and young children are not available in suitable dosage forms. Liquid dosage forms must be prepared extemporaneously, while using appropriate excipients. However, it is critical to determine the stability of various herpetixa at clinically important concentrations and pediaatria storage conditions.


It is of concern that few funding agencies are willing to support research on the development of stable pedatria dosage forms for pediatric patients. The need for such data will continue, because it is unlikely that all drugs approved for adults will also be labeled simultaneously for potential use in infants and children.

Presentations and publications on stable drug formulations will offer the opportunities for pediatric patients to receive the desired drugs and doses most effectively and safely Au. Essential drugs for infants and children: The safety of acetaminophen and ibuprofen among encefaljtis younger than two years old.

A practitioner-based, randomized clinical trial. The risk of hospitalization with any diagnosis in the 4 weeks after enrollment was 1.

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No children were hospitalized for acute renal failure, anaphylaxis, or Reye’s syndrome. Three children were hospitalized with gastrointestinal bleeding; all 3 had been assigned to treatment with ibuprofen.

These data do not provide any information on the safety of these medications when used for prolonged periods or when used together, regardless of duration Au.

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Prevention of exercise-induced bronchospasm in pediatric asthma patients: A comparison of two salmeterol powder delivery devices. A powder formulation of salmeterol has been shown to prevent exercise-induced bronchospasm EIB in asthmatic children and adults; however, the delivery device Diskhaler; Glaxo Wellcome Inc, Research Triangle Park, NC must hfrpetica reloaded after 4 doses.

A new multidose powder inhaler Diskus provides 60 doses of salmeterol in a blister pack presentation with a dose counter. To evaluate the safety and efficacy of microg salmeterol powder via two different delivery systems Diskhaler and Diskus in preventing EIB in asthmatic children.

A randomized, double-blind, double-dummy, single-dose, placebo-controlled, three-way crossover study was conducted in 24 children 4 to 11 years of lediatria demonstrating EIB and mild to moderate asthma. Serial forced expiratory volume in 1 second FEV 1 was measured before and after treadmill exercise challenges conducted at 1, 6, and 12 hours after study drug administration. Adverse events were also assessed.

During all encefaliitis challenges, EIB-mediated reductions in FEV 1 were minimized or prevented pediayria patients receiving single doses of salmeterol powder compared with placebo. Single doses of salmeterol powder delivered via either system were equally effective in preventing EIB. There were no drug-related adverse events, cardiovascular, or other clinically relevant safety concerns. Day care attendance in the first year of life and illnesses of the upper and lower respiratory tract in children with a familial history of atopy.

To examine the relationship between day care attendance and illnesses of the upper and lower respiratory tract in the first year of life. Prospective birth cohort study. A home visit at 2 to 3 months of age and bimonthly telephone questionnaires were used to obtain information on day care arrangements, home characteristics, respiratory symptoms, and physician-diagnosed illnesses of the upper and lower respiratory tract.

Day care attendance in the first year of life was associated with two or more doctor-diagnosed ear infections OR: For children attending day care, exposure to pets in day care, the presence of a rug or carpet in the area where the child slept in day care, and a nonresidential setting for day care all were independent predictors of two or more doctor-diagnosed ear infections. The results suggest that day care increases the risk of illnesses of the upper and lower respiratory tract in the first year of life for children with a familial history of atopy.

Specific environmental exposures within day care, such as the presence of pets or having a rug or carpet in the area where children sleep, may increase the risk of recurrent ear infections in the first year of life among children with familial history of atopy who encefaliis day care Au.

Early dexamethasone therapy and blood cell count in preterm infants.

Encefalitis (para Padres)

To assess the effects of early postnatal dexamethasone therapy on hematologic values in preterm infants. One group 86 infants received saline and the other group 93 infants received dexamethasone. Dexamethasone was given intravenously every 12 hours in tapering doses: Blood samples were obtained on days 0, 3, 7, 10, 14, 21, and None of the infants received prenatal steroid therapy. Multiple regression analysis revealed significant differences in the values versus time curves of the white blood cell, neutrophil, lymphocyte, basophil, and eosinophil counts between the two groups.

The white blood cell count was significantly higher in the dexamethasone group on days 7 through 14, and this was associated with significantly higher numbers of segmented neutrophils and band forms and significantly lower numbers of lymphocytes and eosinophils. The hematocrit and platelet counts were similar in the two groups throughout most of the trial. Except for platelet count, steroid therapy did not alter the hematologic values for infants with bacteremia. Dexamethasone affects white blood cell, segmented neutrophil, lymphocyte, basophil, and eosinophil counts in neonates.

This should be taken into consideration when evaluating preterm infants who are receiving dexamethasone. Perinatal risk factors for infant hospitalization with viral gastroenteritis. A tetravalent vaccine against rotavirus, the most commonly identified etiologic agent of viral gastroenteritis GEhas recently been licensed for use in the United States.